Analyzing Cyber Threats Affecting the Financial Industry

As critical infrastructure, financial institutions must execute the highest level of cybersecurity as the threat of a crippling cyberattack continues to develop. Malicious actors, including disenfranchised employees, state sponsored actors, and traditional hackers, all have motivations to target the financial industry, and do so frequently. However, the threat changes slightly between resource rich large institutions and their smaller, community bank counterparts. The complex and multifaceted threat must be fully understood in order to properly address and analyze solution options to preserve the security of these institutions and the economy that they contribute to

Infant color perception: insight into perceptual development

A remarkable amount of perceptual development occurs in the first year after birth. In this article, we spotlight the case of color perception. We outline how within just 6 months, infants go from very limited detection of color as newborns to a more sophisticated perception of color that enables them to make sense of objects and the world around them. We summarize the evidence that by 6 months, infants can perceive the dimensions of color and categorize it, and have at least rudimentary mechanisms to keep color perceptually constant despite variation in illumination. In addition, infants’ sensitivity to color relates to statistical regularities of color in natural scenes. We illustrate the contribution of these findings to understanding the development of perceptual skills such as discrimination, categorization, and constancy. We also discuss the relevance of the findings for broader questions about perceptual development and identify directions for research

Learning from patients : trainers' use of narratives for learning and teaching

There is a growing interest in how doctors learn from narratives about individual cases, reflected, for example, in the use of e-portfolios. This study aimed to evaluate how GP trainers conceptualised 'learning from patients', and what use they currently made of narrative recounts in training. Thematic analysis (TA) and corpus-linguistic (CL) analysis, with data collected from a convenience sample of trainers in the UK, Ireland, and Spain. GP trainers in the three settings were contacted, and volunteers recruited (22 in UK, 24 in Ireland, and 16 in Spain). Volunteers were interviewed and asked to offer a narrative about 'a patient you learned from' and whether they used narratives as a training device. There were no differences between settings. Trainers described an engaged and personal relationship with patients. They described learning about themselves, the human condition, and about how to live and die well. Their narratives were structured in various ways. At times, they led to precise conclusions: at times, they were perceived as meaningful, but resisting analysis. As regards teaching through narrative, it was reported as commonly used, but present practice appears ad hoc rather than planned. The lack of difference between settings suggests a degree of commonality about how trainers perceive learning and teaching in the areas explored, but cannot be generalised further. The level of personal engagement was more than anticipated, and suggests the label 'doctor-patient relationship', as the term is used, may not be adequate to describe the nature of some interactions

Biological origins of color categorization

The biological basis of the commonality in color lexicons across languages has been hotly debated for decades. Prior evidence that infants categorize color could provide support for the hypothesis that color categorization systems are not purely constructed by communication and culture. Here, we investigate the relationship between infants’ categorization of color and the commonality across color lexicons, and the potential biological origin of infant color categories. We systematically mapped infants’ categorical recognition memory for hue onto a stimulus array used previously to document the color lexicons of 110 nonindustrialized languages. Following familiarization to a given hue, infants’ response to a novel hue indicated that their recognition memory parses the hue continuum into red, yellow, green, blue, and purple categories. Infants’ categorical distinctions aligned with common distinctions in color lexicons and are organized around hues that are commonly central to lexical categories across languages. The boundaries between infants’ categorical distinctions also aligned, relative to the adaptation point, with the cardinal axes that describe the early stages of color representation in retinogeniculate pathways, indicating that infant color categorization may be partly organized by biological mechanisms of color vision. The findings suggest that color categorization in language and thought is partially biologically constrained and have implications for broader debate on how biology, culture, and communication interact in human cognition

3D-HST: A wide-field grism spectroscopic survey with the Hubble Space Telescope

We present 3D-HST, a near-infrared spectroscopic Treasury program with the Hubble Space Telescope for studying the processes that shape galaxies in the distant Universe. 3D-HST provides rest-frame optical spectra for a sample of ~7000 galaxies at 1<z<3.5, the epoch when 60% of all star formation took place, the number density of quasars peaked, the first galaxies stopped forming stars, and the structural regularity that we see in galaxies today must have emerged. 3D-HST will cover 3/4 (625 sq.arcmin) of the CANDELS survey area with two orbits of primary WFC3/G141 grism coverage and two to four parallel orbits with the ACS/G800L grism. In the IR these exposure times yield a continuum signal-to-noise of ~5 per resolution element at H~23.1 and a 5sigma emission line sensitivity of 5x10-17 erg/s/cm2 for typical objects, improving by a factor of ~2 for compact sources in images with low sky background levels. The WFC3/G141 spectra provide continuous wavelength coverage from 1.1-1.6 um at a spatial resolution of ~0."13, which, combined with their depth, makes them a unique resource for studying galaxy evolution. We present the preliminary reduction and analysis of the grism observations, including emission line and redshift measurements from combined fits to the extracted grism spectra and photometry from ancillary multi-wavelength catalogs. The present analysis yields redshift estimates with a precision of sigma(z)=0.0034(1+z), or sigma(v)~1000 km/s. We illustrate how the generalized nature of the survey yields near-infrared spectra of remarkable quality for many different types of objects, including a quasar at z=4.7, quiescent galaxies at z~2, and the most distant T-type brown dwarf star known. The CANDELS and 3D-HST surveys combined will provide the definitive imaging and spectroscopic dataset for studies of the 1<z<3.5 Universe until the launch of the James Webb Space Telescope.Comment: Replacement reflects version now accepted by ApJS. A preliminary data release intended to provide a general illustration of the WFC3 grism data is available at http://3dhst.research.yale.edu

ColourSpot, a novel gamified tablet-based test for accurate diagnosis of color vision deficiency in young children

There is a need for a straightforward, accessible and accurate pediatric test for color vision deficiency (CVD). We present and evaluate ColourSpot, a self-administered, gamified and color calibrated tablet-based app, which diagnoses CVD from age 4. Children tap colored targets with saturations that are altered adaptively along the three dichromatic confusion lines. Two cohorts (Total, N = 772; Discovery, N = 236; Validation, N = 536) of 4–7-year-old boys were screened using the Ishihara test for Unlettered Persons and the Neitz Test of Color Vision. ColourSpot was evaluated by testing any child who made an error on the Ishihara Unlettered test alongside a randomly selected control group who made no errors. Psychometric functions were fit to the data and “threshold ratios” were calculated as the ratio of tritan to protan or deutan thresholds. Based on the threshold ratios derived using an optimal fitting procedure that best categorized children in the discovery cohort, ColourSpot showed a sensitivity of 1.00 and a specificity of 0.97 for classifying CVD against the Ishihara Unlettered in the independent validation cohort. ColourSpot was also able to categorize individuals with ambiguous results on the Ishihara Unlettered. Compared to the Ishihara Unlettered, the Neitz Test generated an unacceptably high level of false positives. ColourSpot is an accurate test for CVD, which could be used by anyone to diagnose CVD in children from the start of their education. ColourSpot could also have a wider impact: its interface could be adapted for measuring other aspects of children’s visual performance

Arene–Ruthenium(II) Acylpyrazolonato Complexes: Apoptosis-Promoting Effects on Human Cancer Cells

A series of ruthenium(II) arene complexes with the 4-(biphenyl-4-carbonyl)-3-methyl-1-phenyl-5-pyrazolonate ligand, and related 1,3,5-triaza-7-phosphaadamantane (PTA) derivatives, has been synthesized. The compounds have been characterized by NMR and IR spectroscopy, ESI mass spectrometry, elemental analysis, and X-ray crystallography. Antiproliferative activity in four human cancer cell lines was determined by MTT assay, yielding dose- and cancer cell line-dependent IC50 values of 9-34 μM for three hexamethylbenzene-ruthenium complexes, whereas the other metal complexes were much less active. Apoptosis was the mechanism involved in the anticancer activity of such compounds. In fact, the hexamethylbenzene-ruthenium complexes activated caspase activity, with consequent DNA fragmentation, accumulation of pro-apoptotic proteins (p27, p53, p89 PARP fragments), and the concomitant down-regulation of antiapoptotic protein Bcl-2. Biosensor-based binding studies indicated that the ancillary ligands were critical in determining the DNA binding affinities, and competition binding experiments further characterized the nature of the interaction

Social and emotional loneliness among older people living in nursing homes in Spain: a cross-sectional study

Loneliness, little studied in Nursing Homes (NHs), can affect physical and mental health. We aimed to analyze the factors associated with overall, social, and emotional loneliness in 65 residents of 5 NHs from Central Catalonia (Spain), and to verify its prevalence. The sample consisted of 81.5% women with a mean age of 84±7.13 years. The cross-sectional study included older adults aged 65 or over and with preserved cognitive status. De Jong Gierveld Loneliness Scale was used to assess overall loneliness and its subtypes; and sociodemographic and health-related variables were collected. The chi-square (or Fisher’s) test and logistic regression were used for bivariate and multivariate analysis respectively. Prevalence of overall loneliness was 70.7% (95%CI:58.2-81.4), social loneliness 44.6% (95% CI: 33.1-56.6) and emotional loneliness 46.2% (95% CI: 34.5–58.1). Overall loneliness was associated with lower perceived quality of life (Odds Ratio-OR = 5.52, 95% CI:1.25-24.38) and NHs with state subsidized places (OR = 0.19, 95% CI: .05-.74); social loneliness with having 0-1 children (OR = .25, 95% CI: .08-.77), and emotional loneliness with depression (OR = 4.54, 95% CI: 1.28-16.08) and urinary incontinence (UI) (OR = 4.65, 95% CI: 1.23-17.52). Loneliness was present in almost 71% of residents and was associated with type of NH and poorer quality of life, the emotional with depression and UI and the social one with having less than 2 children.La soledad, poco estudiada en las residencias de ancianos, puede afectar a la salud física y mental. Nuestro objetivo es analizar los factores asociados a la soledad global, social y emocional de un total de 65 residentes de 5 residencias de la Cataluña Central (España), y comprobar su prevalencia. La muestra estuvo formada por 81.5% mujeres con una edad media de 84±7.13 años. El estudio transversal incluyó a adultos mayores de 65 años y con estado cognitivo preservado. Se utilizó la Escala de Soledad de De Jong Gierveld para evaluar la soledad general y sus subtipos; y se recogieron variables sociodemográficas y relacionadas con la salud. Se utilizó la prueba de chi-cuadrado (o de Fisher) y la regresión logística para el análisis bivariante y multivariante, respectivamente. La prevalencia de la soledad global fue del 70.7% (IC 95%: 58.2-81.4), la soledad social del 44.6% (IC 95%: 33.1-56.6) y la soledad emocional del 46.2% (IC 95%: 34.5-58.1). La soledad global se asoció con una menor calidad de vida percibida (Odds Ratio-OR = 5.52, IC 95%: 1.25-24.38) y las residencias concertadas (OR = 0.19, IC 95%: 0.05-0. 74); la soledad social con tener 0-1 hijos (OR = 0.25, IC 95%: 0.08-0.77), y la soledad emocional con la depresión (OR = 4.54, IC 95%: 1.28-16.08) y la incontinencia urinaria (UI) (OR = 4.65, IC 95%: 1.23-17.52). La soledad estuvo presente en casi el 71% de los residentes y se asoció con el tipo de residencia y la peor calidad de vida, la emocional con la depresión y la IU y la social con tener menos de 2 hijos